Dock and Pak regulate olfactory axon pathfinding inDrosophila
نویسندگان
چکیده
منابع مشابه
Dock and Pak regulate olfactory axon pathfinding in Drosophila.
The convergence of olfactory axons expressing particular odorant receptor (Or) genes on spatially invariant glomeruli in the brain is one of the most dramatic examples of precise axon targeting in developmental neurobiology. The cellular and molecular mechanisms by which olfactory axons pathfind to their targets are poorly understood. We report here that the SH2/SH3 adapter Dock and the serine/...
متن کاملTrio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila
Correct pathfinding by Drosophila photoreceptor axons requires recruitment of p21-activated kinase (Pak) to the membrane by the SH2-SH3 adaptor Dock. Here, we identify the guanine nucleotide exchange factor (GEF) Trio as another essential component in photoreceptor axon guidance. Regulated exchange activity of one of the two Trio GEF domains is critical for accurate pathfinding. This GEF domain...
متن کاملPak Functions Downstream of Dock to Regulate Photoreceptor Axon Guidance in Drosophila
The SH2/SH3 adaptor protein Dock has been proposed to transduce signals from guidance receptors to the actin cytoskeleton in Drosophila photoreceptor (R cell) growth cones. Here, we demonstrate that Drosophila p21-activated kinase (Pak) is required in a Dock pathway regulating R cell axon guidance and targeting. Dock and Pak colocalize to R cell axons and growth cones, physically interact, and ...
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Timothy R. Henion,1,2 Denitza Raitcheva,1 Robert Grosholz,1 Franziska Biellmann,3 William C. Skarnes,4 Thierry Hennet,3 and Gerald A. Schwarting1,2 1Shriver Center, Waltham, Massachusetts 02452, 2Department of Cell Biology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, 3Institute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland, and 4Wellcome Trust ...
متن کاملFollow Your Nose: Axon Pathfinding in Olfactory Map Formation
Two new studies report how discrete identities of olfactory sensory neurons are converted into a spatial map of axonal connections (Imai et al., 2006; Serizawa et al., 2006). They find that levels of cAMP signals derived from olfactory receptors (ORs) can direct targeting of axons along an axis, and that ORs and neural activity regulate expression of adhesion/guidance molecules in mosaic patter...
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ژورنال
عنوان ژورنال: Development
سال: 2003
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.00356